Starling Records

The Frank--Starling curve.

A basic property of the normal heart is that if its volume is increased, there is an increase in the strength of the contraction. The phenomenon is known as Starling's Law, and as the FrankStarling mechanism. This phenomenon is of great importance. If the heart were unable to increase its output when distended, the distension would become progressively severe. The underlying important relation ...

The Reunion Starling

Principles of Human Physiology (Starling)

Ernest Henry Starling: medical educator.

Medical education in North America changed dramatically during the late nineteenth and early twentieth centuries. Although American medical schools had begun to establish ties with major universities in the 870s,1 few physicians in this country had any meaningful exposure to high quality basic science. According to William G. Rothstein,2 there were 65 medical schools in 860, 75 in 870, 00 i...

Reappraising Starling: the physiology of the microcirculation.

PURPOSE OF REVIEW Vascular permeability is traditionally explained by Starling's principle, describing two opposing forces across the endothelial cell line to maintain compartments in balance. Several contradictions to this principle have recently questioned its validity. RECENT FINDINGS Hydraulic conductivity is kept low by a properly working endothelial surface layer, created by binding and...